iKNOBeads are the world’s first and only magnetic microbeads with controllable morphology, designed to activate immune cells in the fight against diseases. Their uniform bead size ensures batch-to-batch reproducibility, while the bumpy body design maximizes cell interaction, enhancing activation efficiency and reducing the required bead quantity. This innovative approach surpasses traditional activation materials and offers a more effective and economical feeder-free platform for generating high-quality and quantity immune cells for therapy. The adaptability of iKNOBeads technology, through surface modification, allows for a wide range of immunotherapy applications, promising potential breakthroughs in disease treatment that could revolutionize the field and bring hope to millions.